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Description

Inhibition of translation initiation by antisense oligonucleotides via an RNase-H independent mechanism

Dose Range: 200600 mcg daily with gradual titration

For premenopausal women with regular ovulatory cycles, the ovaries remain the primary source of oestrogen, so the impact of fat loss on total oestrogen levels may be less pronounced, though changes in oestrogen metabolism and distribution can still occur